MK 1903

SKU: orb1704365

Description

MK 1903 is a potent and selective full agonist of the hydroxy-carboxylic acid receptor 2 (HCA2/GPR109A). It effectively inhibits forskolin-induced cAMP production in vitro (EC₅₀ = 12.9 nM in CHO cells). This compound is a valuable research tool for studying HCA2 function in metabolic and inflammatory processes, applicable in both cellular and animal models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1268882-43-4
• MW: 164.16
• Purity: 99.96% (May vary between batches)
• Formula: C₈H₈N₂O₂
• SMILES: [H][C@]12C[C@@]1([H])c1[nH]nc(C(O)=O)c1C2
• Target: GPCR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (24.37 mM);DMSO:112.5 mg/mL (685.31 mM);Ethanol:< 8.21 mg/mL

Bioactivity

• In Vivo:
  MK-1903 (Compound R, R-19a ) was well tolerated and produced a robust decrease in plasma-free fatty acids.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MK 1903, MK1903, MK-1903, GPR109A

Compound Identifiers

PubChem CID

49763030