MK-0752

SKU: orb1305251

Description

MK-0752 is a potent γ-secretase inhibitor with an IC50 of 5 nM for reducing Aβ40 production. This small molecule is used in research to study Alzheimer's disease pathology, enabling in vitro and in vivo investigations of amyloid-beta modulation.

Research Area

Neuroscience, Protein Biochemistry, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 471905-41-6
• MW: 442.9
• Purity: 99.55% (May vary between batches)
• Formula: C₂₁H₂₁ClF₂O₄S
• SMILES: OC(=O)CC[C@H]1CC[C@@](CC1)(c1cc(F)ccc1F)S(=O)(=O)c1ccc(Cl)cc1
• Target: Gamma-secretase,Beta Amyloid
• Solubility: DMSO:89 mg/mL (200.95 mM);Ethanol:45 mg/mL (101.6 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.45 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  β-Amyloid:5 nM
• In Vivo:
  In human SH-SY5Y cells, MK-0752 significantly reduces Aβ40 in a dose-dependent manner with an IC50 of 5 nM.
• In Vitro:
  In guinea pigs, oral administration of MK-0752 (10-30 mg/kg) resulted in a dose-dependent reduction of Aβ40 in the plasma, brain, and cerebrospinal fluid. Similarly, in monkeys, MK-0752 (240 mg/kg) was capable of reducing the production of Aβ in the brain.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Gamma secretase, Gammasecretase, Inhibitor, MK 0752, MK0752, MK-0752, inhibit, blood-brain, bAmyloid, barrier, b Amyloid, Aβ40, Aβ, Beta Amyloid, BetaAmyloid, CNS, γ-secretase, β Amyloid, βAmyloid

Compound Identifiers

PubChem CID

9803433