MK-0557

SKU: orb1296077

Description

MK-0557 is a potent, selective, and orally bioavailable neuropeptide Y5 receptor antagonist with a Ki of 1.6 nM. This compound is a valuable research tool for investigating the role of the Y5 receptor in appetite regulation and energy homeostasis, supporting both in vitro binding studies and in vivo pharmacological research.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 328232-95-7
• MW: 406.41
• Purity: 99.88% (May vary between batches)
• Formula: C₂₂H₁₉FN₄O₃
• SMILES: Fc1ccccc1-n1ccc(NC(=O)[C@H]2CC[C@]3(CC2)OC(=O)c2ccncc32)n1
• Target: Neuropeptide Y Receptor
• Solubility: DMSO:25 mg/mL (61.51 mM);10% DMSO+90% Corn Oil:2 mg/mL (4.92 mM)

Bioactivity

• Target IC50:
  Y5 receptor:1.6 nM (Ki)
• In Vivo:
  MK-0557 counteracts the NPY5R-selective agonist's influence on body-weight gain and hyperphagia in C57BL/6J mice, also markedly reducing body-weight gain in diet-induced obese (DIO) mice. A 40% reduction in body-weight gain is achieved by day 35 in lean mice shifted from regular chow to a medium high-fat diet (4.2 kcal/g), following treatment with MK-0557 at a dosage of 30 mg/kg PO QD.
• In Vitro:
  MK-0557 has a Ki=1.3 nM at the human NPY5R, with similar affinities at rhesus, mouse, and rat NPY5R. MK-0557 has no significant binding to the human NPY1R, NPY2R, NPY4R, or mouse NPY6R at concentrations of 10 μM .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NPY receptor, inhibit, MK 0557, MK0557, MK-0557, NeuropeptideYReceptor, Neuropeptide Y Receptor, neuropeptide Y (NPY) Y5 receptor, neuropeptide Y (NPY) receptor, Inhibitor, Y5 receptor

Compound Identifiers

PubChem CID

11491176