MK-0557

SKU: orb1296077

Description

MK-0557

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 328232-95-7
• MW: 406.41
• Purity: 99.88%
• Formula: C₂₂H₁₉FN₄O₃
• SMILES: Fc1ccccc1-n1ccc(NC(=O)[C@H]2CC[C@]3(CC2)OC(=O)c2ccncc32)n1
• Target: Neuropeptide Y Receptor
• Solubility: DMSO:25 mg/mL (61.51 mM);10% DMSO+90% Corn Oil:2 mg/mL (4.92 mM)

Bioactivity

• Target IC50:
  Y5 receptor:1.6 nM (Ki)
• In Vivo:
  MK-0557 counteract the NPY5R Selective agonist's influence on body-weight gain and hyperphagia in C57BL/6J mice, also markedly reducing body-weight gain in diet-induced obese (DIO) mice. A 40% reduction in body-weight gain is achieved by day 35 in lean mice shifted from regular chow to a medium high-fat diet (4.2 kcal/g), following treatment with MK-0557 at a dosage of 30 mg/kg PO Q.
• In Vitro:
  MK-0557 has a K = .3 nM a the human NPY5R, with similar affinities at rhesus, mouse, and rat NPY5R. MK-0557 has no significant binding to the human NPY1R, NPY2R, NPY4R, or mouse NPY6R at concentration of 10 μM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

NPY receptor, inhibit, MK 0557, MK0557, MK-0557, NeuropeptideYReceptor, Neuropeptide Y Receptor, neuropeptide Y (NPY) Y5 receptor, neuropeptide Y (NPY) receptor, Inhibitor, Y5 receptor

Compound Identifiers

PubChem CID

11491176