MK-0536

SKU: orb3210883

Description

MK-0536 is a potent HIV-1 integrase inhibitor that effectively suppresses the replication of wild-type viruses. It retains significant antiviral activity against key resistant mutants such as Y143R and N155H, without exhibiting toxicity to uninfected cells. MK-0536 selectively blocks the integrase strand transfer reaction by chelating magnesium ions at the active site and interacting with viral DNA and enzyme residues. This compound is useful for studying the mechanisms of HIV infection.

Key Properties

• CAS Number: 865298-81-3
• MW: 407.82
• Formula: C₁₉H₁₉ClFN₃O₄
• SMILES: O=C1C(O)=C2C(=O)N(CC3=CC=C(F)C(Cl)=C3)CCC2=C(C(=O)N(C)C)N1C
• Target: HIV Protease

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

HIV Protease