MK-0159

SKU: orb1688105

Description

MK-0159 is a potent, orally bioavailable small molecule inhibitor of CD38, developed for research into cardiac ischemia-reperfusion injury (IRI). It demonstrates cardioprotective effects by mitigating myocardial damage, making it a valuable tool for in vivo and in vitro studies of cardiovascular disease and CD38-related pathways.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 2641484-61-7
• MW: 400.495
• Purity: 99.72% (May vary between batches)
• Formula: C₂₀H₂₄N₄O₃S
• SMILES: COCCO[C@H]1CC[C@@H](CC1)NC(=O)c1cc(nc2[nH]ccc12)-c1cncs1
• Target: CD38
• Solubility: DMSO:80 mg/mL (199.75 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (8.24 mM)

Bioactivity

• Target IC50:
  CD38 (human):22±5 nM|CD38 (mouse):3 nM|CD38 (rat):70 nM
• In Vivo:
  In mice with cardiac ischemia/reperfusion injury, MK-0159 (30 mg/kg; oral) is capable of reducing infarct size.
• In Vitro:
  MK-0159 (0-50 μM, 24 hours) increased the levels of NAD+ both intracellularly and extracellularly in A549 cells and HMVEC cells.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CD38

Compound Identifiers

PubChem CID

156339417