Mitoquinone mesylate

SKU: orb1992776

Description

Mitoquinone mesylate (MitoQ) is a mitochondria-targeted antioxidant linked to a triphenylphosphonium (TPP) cation. It potently inhibits TRAP1 with an IC50 of 0.2 µM and is widely used in research on oxidative stress, aging, and neurodegenerative diseases in both cellular and animal models.

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 845959-50-4
• MW: 678.81
• Purity: 98.36%
• Formula: C₃₈H₄₇O₇PS
• SMILES: [O-]S(=O)(C)=O.O=C(C(CCCCCCCCCC[P+](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)=C4C)C(OC)=C(OC)C4=O
• Target: ROS,Reactive Oxygen Species
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (7.37 mM);DMSO:240 mg/mL (353.56 mM);H2O:10 mg/mL (14.73 mM)

Bioactivity

• Target IC50:
  MHV-A59:0.310 μM|SARS-CoV-2 Delta variant:1.6 μM
• In Vivo:
  METHODS: To investigate the role of Mitoquinone mesylate in acute pancreatitis in mice, mice were treated with Mitoquinone mesylate (10 mg/kg). RESULTS: Treatment with Mitoquinone mesylate significantly reduced pancreatic edema and neutrophil infiltration. Mitoquinone mesylate increased serum amylase in a dose-dependent manner, approximately doubling at higher doses. Mitoquinone mesylate treatment nearly doubled caerulein-induced lung MPO activity at a dose of 10 mg/kg, and serum IL-6 levels were also significantly increased.
• In Vitro:
  METHODS: MDA-MB-231 (breast cancer cells), MDA-MB-231BR (brain metastatic breast cancer cells), and U87MG (glioma cells) were treated with Mitoquinone mesylate and cell proliferation was monitored using a live cell imaging system. RESULTS: Mitoquinone mesylate inhibited cell proliferation (IC50=0.38 μM).

Storage & Handling

• Storage: store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Reactive Oxygen Species, ReactiveOxygenSpecies, inhibit, MitoQ, MitoQ 10, MitoQ mesylate, MitoQ Mesylate, MitoQ10, MitoQ-10, MitoQ10 mesylate, MitoQ10 Mesylate, Mitoquinone, Mitoquinone mesylate, Mitoquinone Mesylate, Inhibitor

Compound Identifiers

PubChem CID

11388331