Mitapivat sulfate hydrate

SKU: orb1739615

Description

Mitapivat sulfate hydrate (AG-348) is a small molecule allosteric activator of erythrocyte pyruvate kinase (PK). It is used in research to investigate pyruvate kinase deficiency, where it has been shown in vitro and in vivo to stabilize the enzyme, increase PK activity, and elevate intracellular ATP levels.

Research Area

Metabolism Research

Key Properties

• CAS Number: 2151847-10-6
• MW: 526.6
• Purity: 99.22%
• Formula: C₂₄H₂₆N₄O₃S 1/2H₂SO₄ 3/2H₂O
• SMILES: O=C(C1=CC=C(C=C1)NS(=O)(=O)C2=CC=CC3=CC=CN=C32)N4CCN(CC4)CC5CC5.O=S(=O)(O)O.O 1/2H2SO4 3/2H2O
• Target: PKM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AG 348 sulfate hydrate, AG348 sulfate hydrate

Compound Identifiers

PubChem CID

171360792