Mitapivat hydrochloride

SKU: orb3028952

Description

Mitapivat (AG-348) hydrochloride is an orally active and selective allosteric activator of pyruvate kinase R (PK-R). It enhances the PK-R-catalyzed conversion of phosphoenolpyruvate to pyruvate, thereby promoting the glycolysis pathway, increasing ATP production in red blood cells, and decreasing 2,3-diphosphoglycerate (2,3-DPG) levels. Mitapivat hydrochloride is being investigated for potential use in the study of pyruvate kinase deficiency and other anemia-related disorders.

Research Area

Metabolism Research

Key Properties

• CAS Number: 2559738-69-9
• MW: 487.014
• Formula: C₂₄H₂₇ClN₄O₃S
• SMILES: Cl.O=C(C1=CC=C(C=C1)NS(=O)(=O)C2=CC=CC3=CC=CN=C32)N4CCN(CC4)CC5CC5
• Target: PKM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PKM