Mirodenafil

SKU: orb1308040

Description

Mirodenafil is a selective phosphodiesterase type 5 (PDE5) inhibitor used in research on erectile dysfunction. It is applied in both in vitro enzymatic assays and in vivo studies to investigate smooth muscle relaxation and hemodynamic effects.

Research Area

Cell Biology, Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 862189-95-5
• MW: 531.67
• Purity: 99.89% (May vary between batches)
• Formula: C₂₆H₃₇N₅O₅S
• SMILES: C(CC)C=1C2=C(N(CC)C1)C(=O)N=C(N2)C3=C(OCCC)C=CC(S(=O)(=O)N4CCN(CCO)CC4)=C3
• Target: PDE,Wnt/beta-catenin,Glucocorticoid Receptor,Apoptosis
• Solubility: DMSO:27.5 mg/mL (51.72 mM)

Bioactivity

• In Vitro:
  The pharmacoki-netics of mirodenafil were not significantly altered by this concurrent administration. Mirodenafil (50 or 100 mg), obviously improved erectile function and was well tolerated in a representative population of Korean men with broad-spectrum ED of various etiologies and severities . Mirodenafil administered with alcohol had a tolerability profile comparable to that of mirodenafil alone . The concurrent administration of mirodenafil with alcohol was not associated with clinically significant hemodynamic changes in these healthy male volunteers in Korea. The coadministration of ketoconazole and rifampicin resulted in significant changes in systemic exposure to mirodenafil, in these healthy Korean male volunteers .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Beta catenin, Alzheimer's disease, Apoptosis, Mirodenafil, NIH3T3, inhibit, MRC-5 cells, erectile dysfunction, HT-22 cells, fibrosis, Glucocorticoid Receptor, Inhibitor, β-catenin, systemic sclerosis, PDE5, phosphodiesterase, Phosphodiesterase (PDE), Wnt, SH-SY5Y, SK 3530, SK3530, SK-3530

Compound Identifiers

PubChem CID

135497803