Miquelianin

SKU: orb1296144

Description

Miquelianin

Research Area

Metabolism Research

Key Properties

• CAS Number: 22688-79-5
• MW: 478.36
• Purity: 99.52%
• Formula: C₂₁H₁₈O₁₃
• SMILES: O[C@H]1[C@H](Oc2c(oc3cc(O)cc(O)c3c2=O)-c2ccc(O)c(O)c2)O[C@@H]([C@@H](O)[C@@H]1O)C(O)=O
• Target: Endogenous Metabolite,stilbene oxidase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.09 mM);DMSO:29.69 mg/mL (62.07 mM)

Bioactivity

• In Vivo:
  Miquelianin treatment, compared to vehicle-control treatment, significantly improves AD-type deficits in hippocampal formation basal synaptic transmission and long-term potentiation .
• In Vitro:
  In vitro studies indicate that miquelianin is able to reach the central nervous system from the small intestine . Miquelianin shows an antioxidant effect in human plasma. At 50 μM, miquelianin suppresses the consumption of the three antioxidants lycopene, β-carotene, and α-tocopherol significantly . Miquelianin significantly reduces the generation of β-amyloid (Aβ) peptides by primary neuron cultures generated from the Tg2576 AD mouse model. It is also capable of interfering with the initial protein-protein interaction of Aβ1–40 and Aβ1–42 . Treatment with 0.1 μM miquelianin suppresses ROS generation, cAMP and RAS activation, phosphorylation of ERK1/2 and the expression of HMOX1, MMP2, and MMP9 genes. Miquelianin suppresses invasion of MDA-MB-231 breast cancer cells and MMP-9 induction and inhibits the binding of [3H]-NA to b2-AR .

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, EndogenousMetabolite, Endogenous Metabolite, Miquelianin, inhibit, stilbene oxidase, stilbeneoxidase, Quercetin 3-O-glucuronide, Quercetin 3-glucuronide

Compound Identifiers

PubChem CID

5274585