Miltirone

SKU: orb1297605

Description

Miltirone is a cytochrome P450 (CYPs) inhibitor and a low-affinity ligand for central benzodiazepine receptors. It is used in pharmacological research to study drug metabolism and neuroactive compound interactions, with applications in both in vitro enzyme assays and in vivo models for metabolic and neurological studies.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 27210-57-7
• MW: 282.38
• Purity: 99.66%
• Formula: C₁₉H₂₂O₂
• SMILES: CC(C)C1=Cc2ccc3c(CCCC3(C)C)c2C(=O)C1=O
• Target: SARS-CoV,GABA Receptor,Lipid,Apoptosis,Cytochromes P450
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.08 mM);DMSO:30 mg/mL (106.24 mM)

Bioactivity

• In Vitro:
  Miltirone inhibited multidrug-resistant P-glycoprotein (P-gp)-overexpressing CEM/ADR5000 cells better than drug-sensitive CCRF-CEM wild-type cells, a phenomenon termed collateral sensitivity. Flow cytometric analyses revealed that Miltirone induced G2/M arrest and apoptosis. Furthermore, Miltirone stimulated reactive oxygen species (ROS) generation and mitochondrial membrane potential (MMP) disruption, which in turn induced DNA damage and activation of caspases and poly ADP-ribose polymerase (PARP). Downregulation of CCNB1 (cyclin B1) and CDC2 mRNA and upregulation of CDKN1A (p21) mRNA were in accord with Miltirone-induced G2/M arrest. Moreover, Miltirone decreased cell adherence to fibronectin. Molecular docking revealed that Miltirone bound to the ATP-binding site of IKK-β

Storage & Handling

• Storage: store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

acid, CYP, GABA Receptor, GABA, Gamma-aminobutyric acid Receptor, GABAReceptor, Inhibitor, inhibit, neurotransmission, PARP, Miltirone, P-gp, ROS, γ-Aminobutyric acid Receptor, γ-aminobutyric

Compound Identifiers

PubChem CID

160142