Milnacipran hydrochloride

SKU: orb1309465

Description

Milnacipran hydrochloride

Research Area

Neuroscience

Key Properties

• CAS Number: 101152-94-7
• MW: 282.81
• Purity: 99.92%
• Formula: C₁₅H₂₃ClN₂O
• SMILES: Cl.C1[C@@H]([C@@]1(C(=O)N(CC)CC)c1ccccc1)CN
• Target: Serotonin Transporter,Norepinephrine
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.07 mM);H2O:28.3 mg/mL (100.07 mM);DMSO:50 mg/mL (176.8 mM)

Bioactivity

• Target IC50:
  SERT:420 nM|NET:77 nM
• In Vivo:
  Over 80% of Milnacipran is excreted in the urine primarily in its unchanged form and as glucuronide conjugates, with less than 10% metabolized through CYP3A4 enzyme-mediated N-deethylation. At high concentration , Milnacipran can inhibit certain li and-gated ion channel receptors, including 5 hT3A IC50 185 μM), nMDA IC50 58.4 μM), and nACh IC50 14.3 μM) receptors.
• In Vitro:
  In rat prefrontal cortex, Milnacipran (10 and 30 mg/kg, p.o.) was found to dose-dependently increase extracellular levels of NA and 5 hT. In antidepressant animal behavioral models, Milnacipran (30 and 60 mg/kg, p.o.) significantly reduced immobility time in the forced swim test in rats. Similarly, in animal models of anxiety, Milnacipran (30 and 60 mg/kg, p.o.) notably decreased immobility time in the conditioned fear stress test. In freely moving guinea pigs' hypothalamus, treatment with Milnacipran (10 mg/kg and 40 mg/kg) resulted in a 57% and 47% reduction in the NA metabolite MHPG respectively furthermore , Milnacipran < 0 mg/kg, i.p.) increased extracellular levels of NA and 5 hT in the hypothalamus of freely moving guinea pigs in a dose-dependent manner.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Serotonin Transporter, SerotoninTransporter, SERT, SLC6A4, Savella, 5-HTT, Dalcipran, Inhibitor, inhibit, norepinephrine transporter (NET), norepinephrine transporter (SERT), Milnacipran HCl, Milnacipran hydrochloride, Milnacipran Hydrochloride, Milnacipran

Compound Identifiers

PubChem CID

163701