Microtubulin-IN-1

SKU: orb3028635

Description

Microtubulin-IN-1 (Compound 8g) is an inhibitor of microtubulin, targeting the colchicine-binding site to disrupt tubulin integrity and induce upregulation of p53 protein expression. It exhibits antiproliferative activity across various cancer cell lines, including NCI-H460, BxPC-3, and HT-29, with IC50 values of 2.4, 1.6, and 2.07 nM, respectively. Additionally, Microtubulin-IN-1 induces cell cycle arrest at the G2/M phase and apoptosis in NCI-H460 cells.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 3025180-14-4
• MW: 444.458
• Formula: C₂₅H₂₁FN₄O₃
• SMILES: C(\C=1N(C(C)C)C=CN1)=C\2/C(=O)N/C(=C\C3=CC(C(=O)C4=CC=C(F)C=C4)=CC=C3)/C(=O)N2
• Target: MDM-2/p53,Microtubule Associated,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

MDM-2/p53,Microtubule Associated,Apoptosis