Micronomicin sulfate

SKU: orb2664836

Description

Micronomicin sulfate, also known as Gentamicin C2b sulfate, is an aminoglycoside antibiotic. Beyond its antibacterial properties, it functions as a neuraminidase N1 inhibitor for influenza A virus, making it a relevant tool for antiviral research in both in vitro and in vivo experimental models.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 66803-19-8
• Formula: C₂₀H₄₁N₅O₇. xH₂O₄S
• SMILES: S(=O)(=O)(O)O.O([C@@H]1[C@@H](O)[C@H](O[C@H]2O[C@H](CNC)CC[C@H]2N)[C@@H](N)C[C@H]1N)[C@@H]3[C@H](O)[C@@H](NC)[C@@](C)(O)CO3. xH2SO4
• Target: Antibiotic,Antibacterial
• Solubility: H2O:30 mg/mL

Bioactivity

• Target IC50:
  Staphylococcus aureus FDA 209 P:0.01 μg/ml (MIC)|Baker 2:0.3 μg/ml (MIC)|Escherichia coli St.M. 589:0.75 μg/ml (MIC)|F 14-BK:0.03 μg/ml (MIC)|R5/W677:0.03 μg/ml (MIC)
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• In Vivo:
  Micronomicin sulfate has shown strong activity against a wide range of bacterial infections in mice, with an acute LD50 (lethal dose) of 93 mg/kg administered intravenously. In subacute toxicity studies, intravenous injections, 4-100 mg/kg Micronomicin sulfate, for 30 consecutive days were used in the test. At a dose of 100 mg/kg, 10 of the Wistar rats (out of a total of 30) died, exhibiting renal dysfunction and ataxia. Renal tissue lesions occurred mainly at doses of 25 mg/kg and above.
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• In Vitro:
  Micronomicin sulfate exhibited significant antibacterial activity with a MIC of 0.01 μg/ml against Staphylococcus aureus FDA 209 P and other strains, and a MIC of 0.75 μg/ml, 0.3 μg/ml, 0.03 μg/ml and 0.03 μg/ml against Escherichia coli St.M. 589, Baker 2, F 14-BK and R5/W677, respectively.In addition, it was found to be effective against Pseudomonas aeruginosa and Klebsiella pneumoniae strains with a MIC range of 0.03-17.5 μg/ml.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Sagamicin sulfate, Gentamicin C2b sulfate, Antibiotic XK-62-2 sulfate

Compound Identifiers

PubChem CID

171808