MI-888 free base

SKU: orb1738457

Description

MI-888 is a potent MDM2 inhibitor (Ki = 0.44 nM) with a superior pharmacokinetic profile and enhanced in vivo efficacy. MI-888 is capable of achieving rapid, complete, and durable tumor regression in two types of xenograft models of human cancer with oral administration and represents the most potent and efficacious MDM2 inhibitor reported to date.

Key Properties

• CAS Number: 1303607-59-1
• MW: 548.48
• Formula: C₂₈H₃₂Cl₂FN₃O₃
• SMILES: C(C(C)(C)C)[C@H]1[C@@]2([C@H]([C@H](C(N[C@H]3C[C@@](C)(O)C3)=O)N1)C4=C(F)C(Cl)=CC=C4)C=5C(NC2=O)=CC(Cl)=CC5
• Target: Others

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice
• Disclaimer: For research use only

Cas No. 1303607-59-1

Compound Identifiers

PubChem CID

53477213