MI-2-2

SKU: orb1305000

Description

MI-2-2 is a potent, cell-permeable small molecule inhibitor that disrupts the menin-MLL protein-protein interaction, exhibiting an IC50 of 46 nM and a Kd of 22 nM for menin. It is a valuable chemical probe for studying menin-dependent transcriptional regulation in leukemia research, applicable in both cellular and biochemical assays.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 1454920-20-7
• MW: 415.5
• Purity: 99.56% (May vary between batches)
• Formula: C₁₇H₂₀F₃N₅S₂
• SMILES: C(C(F)(F)F)C1=CC2=C(N=CN=C2S1)N3CCN(CC3)C=4SC(C)(C)CN4
• Target: Histone Methyltransferase
• Solubility: DMSO:Soluble

Bioactivity

• In Vitro:
  MI-2-2 inhibits the bivalent fragment of MLL, consisting of MBM1 and MBM2, with an IC50 of 520 nM. It effectively suppresses cell proliferation, differentiation, and Hoxa9 expression. Additionally, MI-2-2 shows significant activity at low micromolar concentrations in BMCs transformed with MLL-AF9 and in MV4.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MI 22, MI22, MI-22, MI-2-2, MI 2 2, inhibit, Epigenetic Reader Domain, Inhibitor, Hoxa9 expression, HistoneMethyltransferase, Histone Methyltransferase, leukemia, Menin-MLL, menin-MLL interaction, differentiation, cell proliferation

Compound Identifiers

PubChem CID

72201086