MI-1063

SKU: orb2814329

Description

MI-1063 is a potent and cell-permeable MDM2 antagonist that disrupts the MDM2-p53 interaction, leading to p53 activation and tumor suppression. It demonstrates anti-proliferative activity in hematological cancer cell lines (e.g., RS4-11, MV4-11) and serves as the warhead for the PROTAC degrader MD-265 in oncology research.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1410737-39-1
• MW: 588.5
• Formula: C₃₀H₃₂Cl₂FN₃O₄
• SMILES: O=C1[C@@]2(C3(N[C@@H](C(N[C@H]4CC[C@H](C(O)=O)CC4)=O)[C@@H]2C5=C(F)C(Cl)=CC=C5)CCCCC3)C=6C(N1)=CC(Cl)=CC6
• Target: MDM-2/p53,Ligands for Target Protein for PROTAC

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

71020652