MGD-22

SKU: orb3136658

Description

MGD-22 is a molecular glue and orally active degrader of IKZF1/2/3, with DC50 values of 8.33 nM, 9.91 nM, and 5.74 nM, respectively. It exhibits strong anti-proliferative activity against various hematological cancer cells and induces cell apoptosis (apoptosis). MGD-22 demonstrates significant anti-tumor efficacy in mice with NCI-H929 or WSU-DLCL-2 xenografts. This compound is useful for researching blood cancers, including multiple myeloma (MM), acute myeloid leukemia (AML), and diffuse large B-cell lymphoma (DLBCL).

Research Area

Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2991818-12-1
• MW: 577.68
• Formula: C₃₃H₃₅N₇O₃
• SMILES: N#CC1=CC=C(C=C1)N2CCN(CC3=CC=C(C=C3)CNC4=CC=CC=5C(=O)N(N(C)CC45)C6C(=O)NC(=O)CC6)CC2
• Target: IKZF,PROTACs,Apoptosis,Molecular Glues

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

IKZF,PROTACs,Apoptosis,Molecular Glues