MG-115

SKU: orb1705010

Description

MG-115 (Z-LL-Nva-CHO) is a potent, reversible proteasome inhibitor that selectively targets the chymotrypsin-like activity, with K i values of 21 nM and 35 nM for the 20S and 26S proteasome, respectively. This compound is widely used in cancer research to study proteasome function, p53-dependent apoptosis, and cellular mechanisms in both in vitro and in vivo models.

Research Area

Cell Biology, Protein Biochemistry

Key Properties

• CAS Number: 133407-86-0
• MW: 461.59
• Purity: 97.12% (May vary between batches)
• Formula: C₂₅H₃₉N₃O₅
• SMILES: CCCC(NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C=O
• Target: Apoptosis,Proteasome
• Solubility: 10% DMSO+90% Corn Oil:4 mg/mL (8.67 mM);DMSO:45 mg/mL (97.49 mM)

Bioactivity

• In Vitro:
  MG-115, at concentrations ranging from 0.1 to 10 μM over 24 hours, not only diminishes the viability of HepG2 cells in a dose-dependent manner but also enhances the reporter gene expression driven by CWK 18 DNA condensates. Cell viability assays further confirm that MG-115's exposure leads to a dose-dependent decrease in cell viability, quantitatively inhibiting proteasomal activity with an IC 50 value of 2 μM in HepG2 cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MG 115, MG115, MG-115, 26S proteasome, 20S proteasome, Z-LL-Nva-CHO

Compound Identifiers

PubChem CID

22235288