Ac-Leu-Leu-Nle-CHO (ALLN)

SKU: orb1300637

Description

MG-101 (Calpain inhibitor I) is a potent, cell-permeable inhibitor targeting cysteine proteases such as calpains and cathepsins. It is widely used in vitro and in vivo to study roles in neurodegeneration, muscular dystrophy, and cataract formation, providing a key tool for protease-related pathophysiology research.

Research Area

Cell Biology

Key Properties

• CAS Number: 110044-82-1
• MW: 383.53
• Purity: >98%
• Formula: C₂₀H₃₇N₃O₄
• SMILES: CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)C=O
• Target: Protease
• Solubility: Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 5 mg/ml)

Bioactivity

• In Vitro:
  AI-10-49 displays specific growth inhibition of inv(16)-positive cell line ME-1. AI-10-49 selectively binds to CBFβ-SMMHC, disrupts its binding to RUNX1, and restores RUNX1 transcriptional activity.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ac-LL-norleucinal

Compound Identifiers

PubChem CID

443118