MG-101

SKU: orb1300637

Description

MG-101 (Calpain inhibitor I) is a potent, cell-permeable inhibitor targeting cysteine proteases such as calpains and cathepsins. It is widely used in vitro and in vivo to study roles in neurodegeneration, muscular dystrophy, and cataract formation, providing a key tool for protease-related pathophysiology research.

Research Area

Cell Biology, Protein Biochemistry

Key Properties

• CAS Number: 110044-82-1
• MW: 383.53
• Purity: 98.00%
• Formula: C₂₀H₃₇N₃O₄
• SMILES: CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)C=O
• Target: Apoptosis,Proteasome,Cysteine Protease
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.61 mM);DMSO:81.67 mg/mL (212.94 mM);Ethanol:76 mg/mL (198.16 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vitro:
  AI-10-49 displays specific growth inhibition of inv(16)-positive cell line ME-1. AI-10-49 selectively binds to CBFβ-SMMHC, disrupts its binding to RUNX1, and restores RUNX1 transcriptional activity.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, HCT116, HepG2, MG 101, MG101, MG-101, mitochondria, inhibit, Calpain inhibitor-1, Calpain inhibitor I, Bax, Apoptosis, anti-tumor, ALLN, Ac-LLnL-CHO, colon cancer, CysteineProtease, Cysteine protease, Cysteine Protease, Proteasome, SW480, RKO

Compound Identifiers

PubChem CID

443118