MG-002

SKU: orb3175018

Description

MG-002 is an orally active eIF4A inhibitor. It suppresses mRNA translation by non-productively clamping eukaryotic translation initiation factor 4A (eIF4A) onto RNA, thereby hindering ribosome recruitment and scanning. MG-002 selectively inhibits the growth and metastasis of triple-negative breast cancer (TNBC) tumors and induces apoptosis. It also significantly reduces the expression of c-MYC and cyclin D1 proteins. MG-002 is useful for TNBC research.

Research Area

Cell Biology

Key Properties

• CAS Number: 3076503-34-6
• MW: 503.51
• Formula: C₂₇H₂₅N₃O₇
• SMILES: O[C@]12[C@]([C@@H]([C@@H](C(NOC)=O)[C@H]1O)C3=CC=CC=C3)(OC=4C2=C(OC)N=C(OC)C4)C5=CC=C(C#N)C=C5
• Target: PERK,c-Myc,Apoptosis,CDK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PERK,c-Myc,Apoptosis,CDK