Mexiletine hydrochloride

SKU: orb1309949

Description

Mexiletine hydrochloride is a Class IB antiarrhythmic agent that functions as a voltage-gated sodium channel blocker. It is widely used in cardiovascular research to study arrhythmia mechanisms, employing both in vitro electrophysiology and in vivo animal models to investigate its modulation of cardiac action potentials and Purkinje fiber automaticity.

Research Area

Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 5370-01-4
• MW: 215.72
• Purity: 98.44% (May vary between batches)
• Formula: C₁₁H₁₈ClNO
• SMILES: Cl.CC(N)COc1c(C)cccc1C
• Target: Sodium Channel|||AhR
• Solubility: H2O:21.6 mg/mL (100.13 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (9.27 mM);DMSO:50 mg/mL (231.78 mM)

Bioactivity

• In Vivo:
  Mexiletine shortened the cardiac Purkinje fiber effective response period (ERP) less than the action potential duration (APD), resulting in higher ERP/APD ratios.Mexiletine had no significant effect on atrioventricular conduction velocity, resting membrane potential, sinus node autoregulation, systolic arterial pressure, left ventricular function, or QRS or QT intervals. Mexiletine inhibits the inward flow of sodium ions through inhibition of sodium channels (requiring pulse initiation and conduction), which in turn reduces the rate of action potential elevation.
  Read more...
• In Vitro:
  Mexiletine shortened the cardiac Purkinje fiber effective response period (ERP) less than the action potential duration (APD), resulting in higher ERP/APD ratios.Mexiletine had no significant effect on atrioventricular conduction velocity, resting membrane potential, sinus node autoregulation, systolic arterial pressure, left ventricular function, or QRS or QT intervals. Mexiletine inhibits the inward flow of sodium ions through inhibition of sodium channels (requiring pulse initiation and conduction), which in turn reduces the rate of action potential elevation.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Na+ channels, Na channels, Mexiletine, Mexiletine HCl, Mexiletine hydrochloride, Mexiletine Hydrochloride, KOE 1173, KOE1173, KOE-1173, KOE-1173 (hydrochloride), KO 1173, KO1173, KO-1173, inhibit, myocardial, ischemia, Inhibitor, Class IB, AhR, antiarrhythmic, Sodium Channel, SodiumChannel, Voltage-gated sodium channel

Compound Identifiers

PubChem CID

21467