Mevociclib

SKU: orb1708442

Description

Mevociclib (SY-1365) is a potent and selective covalent CDK7 inhibitor. It has demonstrated anti-tumor activity in preclinical studies, showing efficacy in models of ovarian cancer and acute leukemia, supporting its investigation in both solid and hematological malignancies.

Research Area

Cell Biology

Key Properties

• CAS Number: 1816989-16-8
• MW: 587.11
• Purity: 98.02% (May vary between batches)
• Formula: C₃₁H₃₅ClN₈O₂
• SMILES: CN(C)C\C=C\C(=O)Nc1ccc(nc1)C(=O)N[C@@]1(C)CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12
• Target: CDK
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (6.81 mM);DMSO:125 mg/mL (212.91 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, Mevociclib, lung, cancers, cell, CDK, CDK7, CDK7/CycH/MAT1, Cyclin dependent kinase, SY1365, SY-1365, SY 1365, solid, small, TNBC, tumors, triple negative breast cancer

Compound Identifiers

PubChem CID

118426108