METTL3-IN-11

SKU: orb3173386

Description

METTL3-IN-11 is a highly selective METTL3 inhibitor (IC50 = 45.31 nM), demonstrating greater selectivity for METTL3 over DNMT1, EZH1, MLL1, and PRMT1. It reduces m6A levels in total RNA of MOLM-13 and SKOV3 cells, inducing apoptosis and inhibiting migration. METTL3-IN-11 also decreases expression of m6A downstream target genes (c-MYC and BCL2). It is applicable in ovarian cancer and acute myeloid leukemia research.

Research Area

Cell Biology

Key Properties

• CAS Number: 3069369-05-4
• MW: 472.55
• Formula: C₂₆H₂₈N₆O₃
• SMILES: O=C1C=C(N=CN1CC=2C=CC=CC2O)C(=O)NCC=3N=C4C=CC(=CN4C3)CNCC5CCC5
• Target: Bcl-2 Family,c-Myc

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Bcl-2 Family,c-Myc