Metipranolol

SKU: orb1685343

Description

Metipranolol

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 22664-55-7
• MW: 309.4
• Purity: 98.54% (May vary between batches)
• Formula: C₁₇H₂₇NO₄
• SMILES: CC(C)NCC(O)COc1cc(C)c(OC(C)=O)c(C)c1C
• Target: Adrenergic Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.46 mM);DMSO:25 mg/mL (80.8 mM)

Bioactivity

• Target IC50:
  β2-adrenoceptor:8.4 (pA2)|β1-adrenoceptor:8.3 (pA2)
• In Vivo:
  Metipranolol applied as eye drops promoted cone photoreceptor function in retinas of rd10 mice greater than subcutaneously injected metipranolol. The reduced nitrosative damage and rescue of functional loss of photoreceptors in rd10 mice suggests that metipranolol, a drug with established ocular safety and tolerability, may have potential for treating patients with retinitis pigmentosa.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

stress, peroxidation, β-adrenergic receptor, hypertension, Inhibitor, glaucoma, inhibit, lipid, Metipranolol, Nitrosative, Adrenergic Receptor, AdrenergicReceptor, antioxidant, Beta Receptor

Compound Identifiers

PubChem CID

31477