Methylproamine

SKU: orb1309428

Description

Methylproamine

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 188247-01-0
• MW: 465.59
• Purity: 99.94%
• Formula: C₂₈H₃₁N₇
• SMILES: CN(C)C1=CC(C)=C(C=C1)C1=NC2=CC=C(C=C2N1)C1=NC2=CC=C(C=C2N1)N1CCN(C)CC1
• Target: Others,DNA/RNA Synthesis
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:1 mg/mL (2.15 mM);DMSO:55 mg/mL (118.13 mM)

Bioactivity

• In Vitro:
  Immunocytochemical methods were used to measure the accumulation of phosphorylated H2AX (γH2AX) foci following ionizing radiation (IR) in patient-derived lymphoblastoid cells exposed to methylproamine. Pulsed field gel electrophoresis DNA damage and repair assays were performed to directly interrogate the action of methylproamine on DNA in irradiated cells.Methylproamine-treated cells had fewer γH2AX foci after IR compared to untreated cells. Also, the presence of methylproamine decreased the amount of lower molecular weight DNA entering the gel.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, Methylproamine, DNA/RNA Synthesis, DNA double-strand, Radioprotector

Compound Identifiers

PubChem CID

448201