Methylophiopogonanone A

SKU: orb1221815

Description

Methylophiopogonanone A has anti-inflammatory and anti-oxidative properties. Methylophiopogonanone A has therapeutic potential against cerebral I/R injury through its ability to attenuate BBB disruption by regulating the expression of MMP-9 and tight junction proteins.

Key Properties

• CAS Number: 74805-92-8
• MW: 342.34
• Purity: >98% (HPLC)
• Formula: C₁₉H₁₈O₆
• SMILES: CC1=C(C2=C(C(=C1O)C)OCC(C2=O)CC3=CC4=C(C=C3)OCO4)O
• Target: Others
• Solubility: In Vitro: DMSO : 100 mg/mL (292.11 mM)

Bioactivity

• In Vivo:
  Methylophiopogonanone A (MO-A; 10 mg/kg/d, po) for 2 weeks) protects cardiac function following myocardial I/R injury.
• In Vitro:
  Methylophiopogonanone A (MO-A; 10 μmol/L) significantly decreases apoptosis and cleaved caspase-3 expression, elevated the Bcl-2/Bax ratio and restored NO production. Pretreatment with Methylophiopogonanone A (MO-A) markedly increases the activation of PI3K/Akt/eNOS pathway in H9C2 cells subjected to H/R, and the protective effects of MO-A are abolished in the presence of the PI3K inhibitor wortmannin (100 nmol/L).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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