Methylnissolin

SKU: orb1297161

Description

Methylnissolin, isolated from Astragalus membranaceus, is a bioactive small molecule that inhibits PDGF-BB-induced vascular smooth muscle cell proliferation by blocking the ERK1/2 MAPK pathway. Its mechanism supports research in cardiovascular disease and oncology, with studies indicating antibacterial and anticancer properties in vitro.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 73340-41-7
• MW: 300.31
• Purity: 99.98% (May vary between batches)
• Formula: C₁₇H₁₆O₅
• SMILES: [H][C@@]12COc3cc(O)ccc3[C@]1([H])Oc1c2ccc(OC)c1OC
• Target: ERK,PDGFR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (13.32 mM);DMSO:100 mg/mL (332.99 mM)

Bioactivity

• Target IC50:
  PDGFR:10 μM (IC50)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Astrapterocarpan, 3-Hydroxy-9,10-dimethoxyptercarpan, Inhibitor, Extracellular signal regulated kinases, ERK, Methylnissolin, Platelet-derived growth factor receptor, inhibit, PDGFR

Compound Identifiers

PubChem CID

14077830