Methylbenactyzium Bromide

SKU: orb1300506

Description

Methylbenactyzium Bromide

Research Area

Neuroscience

Key Properties

• CAS Number: 3166-62-9
• MW: 422.36
• Purity: 99.63%
• Formula: C₂₁H₂₈BrNO₃
• SMILES: O=C(OCC[N+](CC)(CC)C)C(C1=CC=CC=C1)(O)C2=CC=CC=C2.[Br-]
• Target: AChR
• Solubility: DMSO:50 mg/mL (118.38 mM)

Bioactivity

• Target IC50:
  mAChR:
• In Vitro:
  TW-37 targets the BH3-binding groove in Bcl-2 where proapoptotic Bcl-2 proteins bind, and shows higher affinity and selectivity for Bcl-2 and Mcl-1 over Bcl-xL with Ki values of 0.29 μM, 0.26 μM and 1.11 μM, respectively. In vitro, TW-37 shows significant anti-proliferative and pro-apoptotic effect in a de novo chemo-resistant WSU-DLCL2 lymphoma cell line and primary cells obtained from a lymphoma patient without effects on normal peripheral blood lymphocytes. TW-37 exhibits the inhibitory effect on both cell growth and cell death in endothelial cell with IC50 of approximately 1.8 μM without effect on the fibroblasts exposed to the same concentration range as the endothelial cells. In addition, TW37 also shows the anti-proliferation effects in MCF-7, LNCaP, and SLK tumor cell lines with the same or lower concentration range than those required to inhibit endothelial cell growth.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Gastrimade, Methylbenactyzine Bromide, Methylbenactyzium, Methylbenactyzium Bromide, Paragone, mAChR, Inhibitor, Noinarin, inhibit, Muscarinic acetylcholine receptor, Semulgin

Compound Identifiers

PubChem CID

18493