Methyl rosmarinate

SKU: orb1297282

Description

Methyl rosmarinate is a bioactive compound isolated from Rabdosia serra, acting as a noncompetitive tyrosinase inhibitor (IC50 = 0.28 mM). It exhibits antioxidative, antifungal, α-glucosidase inhibitory, and MMP-1 inhibitory activities, supporting its research in dermatology, diabetes, and food preservation through in vitro studies.

Research Area

Infectious Disease & Virology, Protein Biochemistry

Key Properties

• CAS Number: 99353-00-1
• MW: 374.34
• Purity: 99.83% (May vary between batches)
• Formula: C₁₉H₁₈O₈
• SMILES: COC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c1ccc(O)c(O)c1
• Target: MMP,Tyrosinase,Anti-infection
• Solubility: DMSO:160 mg/mL (427.42 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.34 mM)

Bioactivity

• Target IC50:
  Tyrosinase:0.28 mM
• In Vitro:
  An initial microtiter dilution assay indicated activity of compounds against S. carnosus LTH1502, whereas esters with chain lengths, RA, n-Methyl rosmarinate (RE1), n-dodecyl rosmarinate (RE12), and n-octadecyl rosmarinate (RE18) were used in a time-kill assay S. carnosus LTH1502. Compounds were added at 0.75 mM in the log phase, 5 mM in the exponential phase, 10 mM in the stationary phase. RA had no effect in the lag and exponential phase but decreased cell counts during the stationary phase. In contrast, RE1 and RE12 decreased cell number in all three phase, will RE12 reducing counts most rapidly. Addition of RE18 did not affect regardless of the growth phase
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Antifection, Antiinfection, Anti-infection, inhibit, Inhibitor, Methyl rosmarinate, MMP, Tyrosinase

Compound Identifiers

PubChem CID

6479915