Methoxychlor

SKU: orb1301640

Description

Methoxychlor is an organochlorine pesticide studied as an endocrine disruptor. It is utilized in research to investigate its effects on calcium homeostasis and cytotoxicity across various in vitro cell models and in vivo toxicological studies.

Research Area

Cell Biology

Key Properties

• CAS Number: 72-43-5
• MW: 345.65
• Purity: 99.75% (May vary between batches)
• Formula: C₁₆H₁₅Cl₃O₂
• SMILES: COc1ccc(cc1)C(c1ccc(OC)cc1)C(Cl)(Cl)Cl
• Target: Apoptosis,Others
• Solubility: DMSO:22.5 mg/mL (65.09 mM)

Bioactivity

• In Vitro:
  In HA59T cells, methoxychlor induced a [Ca2 ]i rise by inducing Ca2 entry via protein kinase C-sensitive Ca2 -permeable channels, without causing Ca2 release from stores. Methoxychlor also induced apoptosis that was independent of [Ca2 ]i rises.
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• Cell Research:
  Fura-2, a Ca2 -sensitive fluorescent dye, was applied to measure [Ca2 ]i. Methoxychlor at concentrations of 0.1-1 μM caused a [Ca2 ]i rise in a concentration-dependent manner. Removal of external Ca2 abolished methoxychlor's effect. Methoxychlor-induced Ca2 influx was confirmed by Mn2 -induced quench of fura-2 fluorescence. Methoxychlor-induced Ca2 entry was inhibited by nifedipine, econazole, SK&F96365, and protein kinase C modulators. Methoxychlor killed cells at concentrations of 10-130 μM in a concentration-dependent fashion. Chelation of cytosolic Ca2 with 1,2-bis(2-aminophenoxy) ethane-N,N,N',N'-tetraacetic acid/AM (BAPTA/AM) did not prevent methoxychlor's cytotoxicity. Methoxychlor (10 and 50 μM) induced apoptosis concentration-dependently as determined by using Annexin V/propidium iodide staining
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Methoxychlor

Compound Identifiers

PubChem CID

4115