Methoxyacetic acid

SKU: orb1692413

Description

Methoxyacetic acid, a metabolite of ethylene glycol monomethyl ether, acts as an HDAC inhibitor. It has been shown in vitro to suppress prostate cancer cell proliferation by triggering cell cycle arrest and apoptotic pathways, making it a useful research tool in oncology and toxicology studies.

Research Area

Cell Biology, Epigenetics & Chromatin, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 625-45-6
• MW: 90.08
• Formula: C₃H₆O₃
• SMILES: COCC(O)=O
• Target: HDAC,Apoptosis,Endogenous Metabolite
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (36.63 mM);DMSO:80 mg/mL (888.1 mM);H2O:80 mg/mL (888.1 mM)

Bioactivity

• In Vivo:
  Methods: Male Fischer rats were treated with Methoxyacetic acid (30, 100, 300 mg/kg, gavage) for 5 consecutive days in the first week and then 3 times a day after a weekend break to study its effects on the rats. Results: Compared with the control group, Methoxyacetic acid administration led to a significant decrease in body weight in rats, severe degeneration of the testicular germinal epithelium, a significant decrease in thymus size, depletion of thymic cortical lymphoid components, and a decrease in bone marrow cellularity. At a dose of 300 mg/kg, it even led to a decrease in red blood cell count, hemoglobin concentration, packed cell volume, and white blood cell count.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Methoxyacetic acid

Compound Identifiers

PubChem CID

12251