Methotrexate disodium

SKU: orb1299308

Description

Methotrexate disodium is a potent inhibitor of dihydrofolate reductase (DHFR), disrupting folate metabolism. It is widely used in cancer research, autoimmune disease models, and in vitro studies of cell proliferation, leveraging its ability to inhibit DNA synthesis in both experimental and therapeutic contexts.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 7413-34-5
• MW: 498.4
• Purity: 99.96% (May vary between batches)
• Formula: C₂₀H₂₀N₈Na₂O₅
• SMILES: [Na+].[Na+].CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O
• Target: Apoptosis,DNA/RNA Synthesis,Antibacterial,Antifolate,ADC Cytotoxin,Dehydrogenase
• Solubility: H2O:40 mg/mL (80.26 mM);DMSO:Slightly soluble

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

reductase, WR19039 disodium, synthesis, RNASynthesis, RNA Synthesis, rheumatoid, Amethopterin disodium, ADCCytotoxin, ADC Cytotoxin, ADC Payload, Antifolate, Apoptosis, antineoplastic, arthritis, CL14377 disodium, DNA, DNASynthesis, DNA Synthesis, DNA/RNA Synthesis, Inhibitor, hDHFR(dihydrofolate reductase), leukemia, inhibit, immunosuppressant, Methotrexate disodium, Methotrexate, lymphoblastic

Compound Identifiers

PubChem CID

11329481