Methotrexate Diglutamate

SKU: orb1987037

Description

Methotrexate diglutamate is a small molecule metabolite of methotrexate found in the liver. It acts as a potent inhibitor of human dihydrofolate reductase (DHFR), making it a valuable tool for studying antifolate mechanisms in cancer research and in biochemical assays investigating nucleotide synthesis.

Research Area

Cell Biology, Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 41600-13-9
• MW: 583.55
• Purity: 98.84% (May vary between batches)
• Formula: C₂₅H₂₉N₉O₈
• SMILES: NC=1C2=C(N=CC(CN(C)C3=CC=C(C(N[C@@H](CCC(N[C@@H](CCC(O)=O)C(O)=O)=O)C(O)=O)=O)C=C3)=N2)N=C(N)N1
• Target: DHFR
• Solubility: DMSO:100 mg/mL (171.36 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DHFR, NSC269401, NSC-269401, NSC 269401

Compound Identifiers

PubChem CID

21144698