Methocarbamol

SKU: orb1224773

Description

Methocarbamol is a central muscle relaxant used to treat skeletal muscle spasms.(In Vitro):Methocarbamol (2 mM; for 20 min) significantly increases the decay times of the EPCs and those of the EPPs induced by the phrenic nerve stimulation.Methocarbamol has no effect on Nav1.7 currents.\n(In Vivo):Methocarbamol (200 mg/kg; ip) has Muscle relaxant activity of 88.96%.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 532-03-6
• MW: 241.24
• Purity: >98% (HPLC)
• Formula: C₁₁H₁₅NO₅
• SMILES: COC1=CC=CC=C1OCC(COC(=O)N)O
• Target: Carbonic Anhydrase
• Solubility: Ethanol: 48 mg/mL (198.97 mM); Water: 2 mg/mL (8.29 mM); DMSO: 48 mg/mL (198.97 mM)

Bioactivity

• In Vivo:
  Methocarbamol (200 mg/kg; ip) has Muscle relaxant activity of 88.96%. Animal model: Mice with weight 20-30 g. Dosage: 200 mg/kg. Administration: IP; single dose. Result: Had Muscle relaxant activity of 88.96%.
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• In Vitro:
  Methocarbamol (2 mM; for 20 min) significantly increases the decay times of the EPCs and those of the EPPs induced by the phrenic nerve stimulation. Methocarbamol has no effect on Nav1.7 currents.
  Read more...

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AHR 85 | Guaiacol Glyceryl Ether Carbamate | Guaiphenesin Carbamate | NSC 170960

Quick Database Links

Gene Symbol

Carbonic Anhydrase