Methionine B

SKU: orb2901550

Description

Methionine (MRX-1024; D-Methionine) is an effective chemoprotective agent which can also inhibit the neuronal activity through GABAA receptor activation.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 348-67-4
• MW: 149.21
• Purity: >98% (HPLC)
• Formula: C₅H₁₁NO₂S
• SMILES: [C@H](C(O)=O)(CCSC)N
• Target: Endogenous Metabolite
• Solubility: In Vitro: H2O : 25 mg/mL (167.55 mM; Ultrasonic)

Bioactivity

• In Vivo:
  When Methionine (D-methionine) is administered along with cisplatin the cell density is 0.8±0.070 (SEM), significantly larger than in rats treated with only cisplatin (P<0.01) while not significantly different from controls or from animals treated only with D-methionine (P>0.05). When Methionine is administered alone the average cell density is 0.95±0.099 (SEM) and not significantly different from controls (P>0.05).
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• In Vitro:
  The incubation of human plasma with Methionine (D-methionine) and CP leads to the formation of a Pt-D-methionine complex independent of the order of addition. In plasma, an early CP hydrolysis product reacts with Methionine to form a 1: 1 complex that is followed by the formation of a 2: 1 compound at a later time point. The formation of these Pt-D-methionine species plays an important role in the processes by which Methionine protects mammalian organisms against CP-induced toxicities.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Endogenous Metabolite