Methazolamide

SKU: orb1310931

Description

Methazolamide (CL 8490) is a potent carbonic anhydrase inhibitor employed in research as a diuretic agent and for studying glaucoma pathophysiology. Its mechanism is utilized in both in vitro enzymatic assays and in vivo models to investigate intraocular pressure regulation and fluid balance.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 554-57-4
• MW: 236.27
• Purity: 98.45% (May vary between batches)
• Formula: C₅H₈N₄O₃S₂
• SMILES: CC(=O)\N=c1\sc(nn1C)S(N)(=O)=O
• Target: Carbonic Anhydrase,ROS,Apoptosis,Caspase
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:60 mg/mL (253.95 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.46 mM);Ethanol:3 mg/mL (12.7 mM)

Bioactivity

• Target IC50:
  CA II (human):14 nM(Ki)|CA I (human):50 nM(Ki)|CA IV (bovine):36 nM(Ki)
• In Vivo:
  Methazolamide is a carbonic anhydrase inhibitor that inhibits hCA I (Ki: 50 nM), hCA II (Ki: 14 nM) and bCA IV (Ki: 36 nM) isoforms.
• In Vitro:
  Methazolamide is a carbonic anhydrase inhibitor that inhibits hCA I (Ki: 50 nM), hCA II (Ki: 14 nM) and bCA IV (Ki: 36 nM) isoforms.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

bCAIV, Carbonate dehydratase, Carbonic Anhydrase, CarbonicAnhydrase, disorders, CL 8490, CL8490, CL-8490, glaucoma, L584601, L-584601, Inhibitor, hCAII, hCAI, inhibit, L 584601, intraocular, Methazolamide, pressure-lowering

Compound Identifiers

PubChem CID

4100