Metformin hydrochloride

SKU: orb1226969

Description

Metformin Hcl, a widely used anti-diabetic drug has potential efficacy as an anti-Y drug. Metformin inhibits the proliferation of a range of Y cells including prostate, colon, breast, ovarian, and glioma lines.(In Vitro):Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) inhibits proliferation of ESCs in a concentration-dependent manner. The IC50 is 2.45 mM for A-ESCs and 7.87 mM for N-ESCs. Metformin shows pronounced effects on activation of AMPK signaling in A-ESCs from secretory phase than in cells from proliferative phase.Metformin hydrochloride (0-500 μM) decreases glycogen synthesis in a dose-dependent manner with an IC50 value of 196.5 μM in cultured rat hepatocytes.Metformin hydrochloride shows cell viability and cytotoxic effects on PC-3 cells with IC50 of 5 mM.(In Vivo):Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride; 100 mg/kg, p.o.) alone, and metformin (25, 50, 100 mg/kg) with NSC 37745 groups attenuates myocyte necrosis through histopathological analysis.

Key Properties

• CAS Number: 1115-70-4
• MW: 165.63
• Purity: >98% (HPLC)
• Formula: C₄H₁₂ClN₅
• SMILES: Cl.CN(C)C(=N)N=C(N)N
• Target: AMPK
• Solubility: Water: 33 mg/mL warmed (199.25 mM)

Bioactivity

• In Vivo:
  Metformin hydrochloride (1, 1-Dimethylbiguanide hydrochloride; 100 mg/kg, p.o.) alone, and metformin (25, 50, 100 mg/kg) with NSC 37745 groups attenuates myocyte necrosis through histopathological analysis.
• In Vitro:
  Metformin hydrochloride (1, 1-Dimethylbiguanide hydrochloride) inhibits proliferation of ESCs in a concentration-dependent manner. The IC50 is 2.45 mM for A-ESCs and 7.87 mM for N-ESCs. Metformin shows pronounced effects on activation of AMPK signaling in A-ESCs from secretory phase than in cells from proliferative phase. Metformin hydrochloride (0-500 μM) decreases glycogen synthesis in a dose-dependent manner with an IC50 value of 196.5 μM in cultured rat hepatocytes. Metformin hydrochloride shows cell viability and cytotoxic effects on PC-3 cells with IC50 of 5 mM.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

1,1-Dimethylbiguanide hydrochloride

Quick Database Links

Gene Symbol

AMPK