Metarrestin

SKU: orb1309433

Description

Metarrestin (ML246) is a first-in-class small molecule inhibitor that targets the perinucleolar compartment, disrupting nucleolar structure and suppressing RNA Pol I transcription via interaction with eEF1A2. It demonstrates a favorable pharmacokinetic profile and has been shown to effectively inhibit metastatic progression in both in vitro and in vivo cancer models.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 1443414-10-5
• MW: 474.6
• Purity: 99.45%
• Formula: C₃₁H₃₀N₄O
• SMILES: O[C@H]1CC[C@@H](CC1)n1cnc2n(Cc3ccccc3)c(c(-c3ccccc3)c2c1=N)-c1ccccc1
• Target: DNA/RNA Synthesis
• Solubility: DMSO:4.75 mg/mL (10.01 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

compartment, breast, DNA/RNA Synthesis, DNA Synthesis, DNASynthesis, pancreatic, PANC1, PC3M, Metarrestin, metastatic, nucleolar, orally, ML246, ML-246, ML 246, inhibit, eEF1A2, Inhibitor, HeLa, perinucleolar, RNASynthesis, RNA polymerase (Pol) I, RNA polymerase I, RNA Synthesis, transcription

Compound Identifiers

PubChem CID

50985821