Mesutoclax

SKU: orb3135710

Description

Mesutoclax (ICP-248) (Compound 5) is a selective BCL-2 inhibitor with an IC50 of 1.54 nM, demonstrating weak activity against BCL-XL (IC50: >1000 nM). Mesutoclax (ICP-248) (Compound 5) inhibits the viability of RS4;11 cells with an IC50 of 2.75 nM and is therefore used in apoptosis and cancer cell biology research systems to investigate BCL-2–mediated survival signaling, intrinsic apoptotic pathway activation, and leukemia cell viability regulation.

Research Area

Cell Biology

Key Properties

• CAS Number: 2760536-87-4
• MW: 884.44
• Purity: 98.96% (May vary between batches)
• Formula: C₄₅H₅₀ClN₇O₈S
• SMILES: CC(C)(CC1)CC(C2=CC=C(C=C2)Cl)=C1CN3[C@@H](CN(C4=CC(OC5=CN=C(NC=C6)C6=C5)=C(C=C4)C(NS(=O)(C7=CC([N+]([O-])=O)=C(C=C7)NC[C@H]8COCCO8)=O)=O)CC3)C
• Target: Bcl-2 Family

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Bcl-2 Family