MerTK/Axl-IN-1

SKU: orb2665126

Description

MerTK/Axl-IN-1 (A-910) is a potent, selective dual inhibitor of MerTK and Axl kinases, demonstrating low nanomolar IC50 values in both cellular (Ba/F3) and biochemical (HTRF) assays. It shows robust in vivo target engagement by inhibiting pMerTK, coupled with favorable pharmacokinetic properties including a long half-life and high oral bioavailability, making it a valuable tool for cancer and immunology research.

Research Area

Signal Transduction

Key Properties

• CAS Number: 3036009-40-9
• MW: 694.84
• Formula: C₄₀H₄₇FN₆O₄
• SMILES: C([C@@H](CO)O)N1CCN([C@@H]2C=3C(=CC(=CC3)C4=CC=C(CO[C@@H]5[C@@H](NC(=O)C=6C=C(C=NC6N)C7=C(F)N=CC=C7)CCC5)C=C4)CCC2)CC1
• Target: TAM Receptor

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

171524864