Mertansine

SKU: orb1226372

Description

Mertansine (DM1) is a tubulin inhibitor; thiol-containing maytansinoid that create an antibody-drug conjugate (ADC); an ADC payload.(In Vitro):Mertansine is a strong antiproliferative chemotherapeutics toward over 60 types of cancer cell lines.Mertansine (0-1 μg/mL) shows antitumor activity in malignant B16F10 melanoma cells, and inhibits tumor cell growth by inhibiting mitosis when combined with DTX.(In Vivo):Mertansine (DM1) has a low maximum-tolerated dose (MTD) of 1 mg/kg.

Key Properties

• CAS Number: 139504-50-0
• MW: 738.2877
• Purity: >98% (HPLC)
• Formula: C₃₅H₄₈ClN₃O₁₀S
• SMILES: C[C@@H]1[C@@H]2C[C@]([C@@H](/C=C\C=C(\CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)C[C@H]([C@]4(C1O4)C)OC(=O)[C@H](C)N(C)C(=O)CCS)C)/C)OC)(NC(=O)O2)O
• Target: ADC Cytotoxin
• Solubility: DMSO: ≥ 83.33 mg/mL

Bioactivity

• In Vitro:
  Cell Proliferation Assay Cell line: Malignant B16F10 melanoma cells. Concentration: 0, 0.01, 0.1, and 1 μg/mL Incubation time: 4 h. Result: Showed antitumor activity in malignant B16F10 melanoma cells, with an IC50 of 0.092 μg/mL. Co-delivery of DTX and DM1, both of which inhibit tumor cell growth by inhibiting mitosis, is an effective strategy to achieve a combinatorial anticancer effect.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DM1 | Maytansinoid DM1 | DM-1 | Maytansinoid DM-1

Quick Database Links

Gene Symbol

ADC Cytotoxin