Merbarone

SKU: orb3177614

Description

Merbarone is a Type II DNA topoisomerase inhibitor that suppresses the catalytic activity of human topoisomerase IIα by blocking DNA cleavage, subsequently inducing activation of caspase-activated DNase and excision of chromosomal DNA loops from the nuclear matrix, Merbarone triggers apoptosis in CEM cells through activation of ICE/CED-3-like proteases, making it a mechanistically informative compound for studying DNA damage responses and apoptosis pathways.

Key Properties

• CAS Number: 97534-21-9
• MW: 263.27
• Purity: 99.51% (May vary between batches)
• Formula: C₁₁H₉N₃O₃S
• SMILES: O=C(NC=1C=CC=CC1)C2C(=O)NC(=S)NC2=O
• Target: Topoisomerase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Topoisomerase