Menthol

SKU: orb1301551

Description

DL-Menthol is a synthetic or naturally derived compound from mint oils, known for its cooling flavor and local anesthetic properties. It is widely used in research as a TRPM8 channel agonist for studying thermosensation, pain, and inflammation in both in vitro and in vivo models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1490-04-6
• MW: 156.26
• Purity: 99.88% (May vary between batches)
• Formula: C₁₀H₂₀O
• SMILES: CC(C)C1CCC(C)CC1O
• Target: Calcium Channel
• Solubility: DMSO:50 mg/mL (319.98 mM)

Bioactivity

• In Vivo:
  High levels of the major DL-Menthol metabolite, menthol-glucuronide, was observed in the urine of smokers of either menthol or non-menthol cigarettes. The fact that a significant inverse correlation was observed between the levels of urinary menthol-glucuronide and NNAL-N-glucuronide, a major detoxification metabolite of the tobacco carcinogen, NNK, suggests that menthol may be inhibiting the clearance of this important tobacco carcinogen.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Calcium Channel, CalciumChannel, DL-Menthol, Menthol

Compound Identifiers

PubChem CID

1254