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Menin-MLL inhibitor MI-2 dihydrochloride

SKU: orb3136082

Description

Menin-MLL inhibitor MI-2 dihydrochloride is a competitive and selective inhibitor of the Menin-MLL interaction, with an IC50 value of 446 nM and a Ki value of 158 nM. It reduces the expression of target genes such as HOXA9 and MEIS1, inhibits the proliferation of leukemic cells, and induces apoptosis and differentiation. Menin-MLL inhibitor MI-2 dihydrochloride shows potential for research in MLL-rearranged acute leukemias, such as acute myeloid leukemia and acute lymphoblastic leukemia.

Research Area

Cell Biology, Epigenetics & Chromatin, Epigenetics & Chromatin; Pharmacology & Drug Discovery

Images & Validation

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Menin-MLL inhibitor MI-2 dihydrochloride

Key Properties

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TargetApoptosis,Epigenetic Reader Domain

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Quick Database Links

Gene Symbol
Apoptosis,Epigenetic Reader Domain

Protocol Information

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