Menadione bisulfite sodium

SKU: orb1301382

Description

Menadione sodium bisulfite is a water-soluble form of vitamin K3, clinically used to treat deficiency-related hemorrhage. It serves as a key research compound for studying vitamin K's role in coagulation, bone metabolism, and redox biology in both cellular and animal models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 130-37-0
• MW: 276.24
• Purity: 95.00% (May vary between batches)
• Formula: C₁₁H₉NaO₅S
• SMILES: [Na+].CC1(CC(=O)c2ccccc2C1=O)S([O-])(=O)=O
• Target: Others,Endogenous Metabolite
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.24 mM);DMSO:20 mg/mL (72.4 mM)

Bioactivity

• In Vitro:
  MSB inhibited Aβ42 amyloid formation in a dose dependent manner, delayed the secondary structural conversion of Aβ42 from random coil to ordered β-sheet, and attenuated the ability of Aβ42 aggregates to disrupt membranes; moreover, the quinone backbone rather than lipophilicity is esstial for the inhibitory effects of MSB. Next, in cells expressing a pathogenic APP mutation (Osaka mutation) that results in the formation of intraneuronal Aβ oligomers, MSB inhibited the intracellular aggregation of Aβ. Moreover, MSB treatment significantly extended the life span of Caenorhabditis elegans CL2120, a strain that expresses human Aβ42. Together, these results suggest that MSB and its derivatives may be further explored as potential therapeutic agents for the prevention or treatment of Alzheimer's disease(AD).

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, Menadione bisulfite, Menadione bisulfite sodium, Menadione sodium bisulfite, Menadione sodium Bisulfite, Sodium menadione bisulfite, Sodium menadione Bisulfite, Vitamin K3 sodium Bisulfite, Vitamin K3 sodium bisulfite

Compound Identifiers

PubChem CID

23665888