MELK-IN-1

SKU: orb1309436

Description

MELK-IN-1 is a highly potent and selective small molecule inhibitor of Maternal Embryine Leucine Zipper Kinase (MELK), exhibiting an IC50 of 3 nM and a Ki of 0.39 nM. This compound is a valuable chemical probe for investigating MELK function in cancer cell proliferation, stem cell biology, and tumor growth in both cellular and animal models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2095596-44-2
• MW: 539.62
• Purity: 99.84% (May vary between batches)
• Formula: C₃₁H₃₃N₅O₄
• SMILES: COC(=O)c1ccc2NC(=O)\C(=C(/Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)c2c1
• Target: MELK
• Solubility: DMSO:Insoluble

Bioactivity

• Target IC50:
  MELK:0.39 nM(Ki)|MELK:3 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Nintedanib Impurity L, Inhibitor, MELK, MELKIN1, MELK-IN-1, MELK IN 1, MELK inhibitor 17, Maternal embryonic leucine zipper kinase

Compound Identifiers

PubChem CID

137248544