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MELK-8a
Catalog Number: orb1687627
| Catalog Number | orb1687627 |
|---|---|
| Category | Small Molecules |
| Description | MELK-8a |
| CAS Number | 1922153-17-0 |
| Purity | 98% |
| MW | 432.56 |
| SMILES | O(CC1CCNCC1)C=2C(=CC=NC2)C3=CN(N=C3)C4=CC=C(C=C4)N5CCN(C)CC5 |
| Formula | C25H32N6O |
| Biological Activity | MELK-8a (NVS-MELK8a) is a highly potent and selective maternal embryonic leucine zipper kinase ( MELK ) inhibitor with IC 50 of 2 nM. MELK-8a also inhibits Flt3 (ITD), Haspin, PDGFRα with IC 50 s of 0.18, 0.19, and 0.42 μM, respectively. MELK plays an essential role in regulating cell mitosis in a subset of cancer cells [1]. |
| Storage | -20°C |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
MELK-8a hydrochloride [orb1309437]
99.87%
2096992-20-8
469.02
C25H33ClN6O
200 mg, 100 mg, 5 mg, 10 mg, 25 mg, 50 mg, 1 ml x 10 mm (in DMSO), 2 mg
