Melicopine

SKU: orb2813789

Description

Melicopine is an alkaloid found in Z. simulans, known for its antimalarial and anticancer properties. It inhibits P. falciparum strains, including chloroquine-sensitive 3D7 (IC50 of 29.7 µg/mL) and chloroquine-resistant Dd2 (IC50 of 33.7 µg/mL). Additionally, Melicopine exhibits cytotoxicity against prostate cancer cells PC-3M (IC50 of 47.9 µg/mL) and LNCaP (IC50 of 37.8 µg/mL), but it is inactive in non-cancerous HEK293 cells (IC50 greater than 100 µg/mL). Melicopine holds potential for research in anticancer and anti-infective applications.

Key Properties

• CAS Number: 568-01-4
• MW: 313.31
• Formula: C₁₇H₁₅NO₅
• SMILES: O=C1C=2C=CC=CC2N(C3=C4OCOC4=C(OC)C(OC)=C13)C
• Target: Parasite

Storage & Handling

• Storage: -20°C
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Parasite