MEK inhibitor

SKU: orb1709157

Description

This small molecule MEK inhibitor suppresses the RAS/RAF/MEK/ERK signaling pathway, demonstrating antitumor activity. It is widely used in cancer research to investigate tumor cell proliferation and signaling in both in vitro assays and in vivo xenograft models, particularly for malignancies with RAS/RAF mutations.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 334951-92-7
• MW: 426.51
• Purity: 97.48% (May vary between batches)
• Formula: C₂₆H₂₆N₄O₂
• SMILES: C(\NC1=CC(CN(C)C)=CC=C1)(=C\2/C=3C(NC2=O)=CC(C(NC)=O)=CC3)/C4=CC=CC=C4
• Target: MEK
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.69 mM);DMSO:50 mg/mL (117.23 mM)

Bioactivity

• In Vitro:
  MEK inhibitor is a potent inhibitor of MEK (mitogen-activated protein kinase), a kinase responsible for phosphorylating MAPKs (mitogen-activated protein kinases), and activated MAPKs further phosphorylate downstream transcription factors to regulate a variety of biological responses, including stress signaling, pathogen response, and hormone signaling. Inhibition of MEK leads to inhibition of MAPK phosphorylation and inhibition of biological responses downstream of MAPK.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MEK inhibitor, MEK

Compound Identifiers

PubChem CID

135742497